Obesity Health or Feminist Issue

Obesity is one of the urgent problems of the modern society. These days, this problem bothers minds of almost all women around the world. There are many issues related to the problem of overweight, the discussions are spreading far behind the health problems related to obesity, they reach cultural, social and psychological dimensions. When it comes to obesity issue, most of us will readily agree that it is rather a female problem than a male one.Advertising We will write a custom essay sample on Obesity: Health or Feminist Issue? specifically for you for only $16.05 $11/page Learn More In the light of pursuit of modern women to correspond to contemporary ideals of beauty and, at the same time to be independent of the social standards, obesity becomes a feminist issue, as it is widely considered to be a â€Å"rebellion against the powerlessness of the woman, against the pressure to look and act in a certain way and against being evaluated on her ability to create an image of herself† (Orbach 204). There this agreement usually ends, however, on the question of woman’s independence and her health, the issue of obesity provides a topic for further discussions. Whereas some are convinced that obesity is a rebellion against social standards, others maintain that obesity is entirely a health and psychological problem that cannot be associated with feminism and should be discussed only as a medical issue. I’m of two minds about the issue of obesity. On the one hand, I agree that women should fight with standards of beauty that are laid upon them by means of media and ideal appearance of top models that look at ordinary women from glance magazines and ads. On the other hand, I’m not sure if overweight can be a good means to fight against sex inequality and means to proclaim woman’s independence. Thus, I argue that obesity is a big problem, but one should not run to extremes and take obesity only as â€Å" a response to the inequality of the sexes† (Orbach 204), but it should regard it as a health problem as well. Indeed, it goes without saying that even in a modern society woman cannot be completely equal to man. This inequality goes much further than social right and other political or social issues. The problem lies much deeper and it deal with stereotypes and psychology of both sexes. Modern media provides two images of a woman, thus dictating priorities for her and dividing her life in two major periods. The first period is when she is not married and should find a man to create a future family: during this period she should be pretty and sexy. The second period is her family life when she should support her husband and children and be a perfect â€Å"mistress†. This woman’s â€Å"functions† are not emphasized, but widely provided and create stereotypes. In addition, the relationships between man and women are identified as â€Å"man looks at women.Adv ertising Looking for essay on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More Woman watches themselves being looked at† (Orbach 202). Consequently, this makes a woman to be responsible for her â€Å"good look† and emphasizes â€Å"presentation as the central aspect of a woman’s existence and makes her extremely self-conscious† (Orbach 202). Such situation can be commented with words by Susie Orbach that â€Å"the woman’s body is not her own (203). In their fight against these stereotypes, feminists claim that: â€Å"Being fat represents an attempt to break free of society’s sex stereotype. Getting fat can thus be understood as a definite and purposeful act; it is a direct, conscious or unconscious, challenge to sex-role stereotyping and culturally defined experience of womanhood† (Orbach 201). In this light, being fat can be considered as an attempt to show one’s indivi duality and independence. However, is this the only reason why women put weight? Yves Engler claims that â€Å"advertising fatty foods and putting delicious looking pictures for all to see is the cause of our fat† (120). Indeed, in some extend we are forced to be dependent on fatty food and fast food which is around us. It can even become a psychological addiction. Hardly a woman who eats a hamburger is too concerned about her independency and individuality. Randy Balko writes that â€Å"the main cause of obesity lies within a person’s own responsibility† (343). Thus, if you are fat, it is all your responsibility. Orbach partially supports these opinions, but she still emphasizes that women eat fat food not because they do not have a willpower, but rather because they want to ruin the social norms and ideals provided by the media industry. It is obvious that having a perfect body is a mania, rather than a desire to be healthy: â€Å"In the United States, a woma n with a lean, strong, and well-sculpted body is the ideal. Many who do not fit the ideal struggle with feelings of guilt and shame. The percentage of women with body image disturbance is alarming and those with overweight and obesity struggle to meet the ideal† (Buxton 285) In this light, women should deal with pressure to confront to the perfect stereotype from the glance magazine, but as it has already been mentioned, she should not run to extremes. I argue that obesity is an extreme, as it is also associated with health problems.Advertising We will write a custom essay sample on Obesity: Health or Feminist Issue? specifically for you for only $16.05 $11/page Learn More The health problems related to obesity include â€Å"coronary heart disease, type 2 diabetes, cancers (endometrial, breast, and colon), hypertension (high blood pressure), dyslipidemia, stroke, liver and gallbladder disease, sleep apnea and respiratory problems, osteoarthritis, gynecological problems (abnormal menses, infertility)† (â€Å"Overweight and Obesity† n. p.). Thus, one question arises: â€Å"Is it worth being fat, but independent if it impacts your heal so much?† I support the idea, that obesity is a problem and feminists should not proclaim it as a form of rebellion against social standards. Moreover, â€Å"As one talks about the body, in addition to the physical dimensions, one must also consider cultural, political, and symbolic construct. Each of these four dimensions impact the psychological dimension of the body or body image† (Buxton 285). People are different and their bodies are also very different. Consequently, all people have different attitudes to the way a woman should look like. In fact, tastes differ and it does not mean that all men like only slim women and all girls should be thin or fat to show their individuality. Fat is not good for one’s health. Thus, if feminists use obesity as a form of rebel, it can be said that they use health problem as a form of rebel as well. Thus, obesity is the issue that should not be taken lightly. It cannot be used for ideological or personal purposes. Whereas obesity breaks social standards, it impacts greatly one’s health. In this light, I strongly support the idea that one should keep within limits and develop wise attitudes towards his/her health, as well as appearance. Works Cited Barbara K. Buxton. â€Å"Body Image and Women: How Does Obesity Fit into the Picture†Bariatric Nursing and Surgical Patient Care, 3(4): 285-290. Web. Balko, Radley. â€Å"What You Eat Is Your Business†. In They Say I Say. The Moves That Matter in Academic Writing (With Readings). Ed. Gerald Graff, Cathy Berkenstein, and Russel Durst. New York: Norton, 2009. Engler, Yves. â€Å"Obesity: Much of the Responsibility Lies with Corporations.† In They Say I Say. The Moves That Matter in Academic Writing (With Readings). Ed. Gerald Graff , Cathy Berkenstein, and Russel Durst. New York: Norton, 2009.Advertising Looking for essay on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More Orbach, Susie. â€Å"Fat as a Feminist Issue.† In They Say I Say. The Moves That Matter in Academic Writing (With Readings). Ed. Gerald Graff, Cathy Berkenstein, and Russel Durst. New York: Norton, 2009. â€Å"Overweight and Obesity: Health Consequences.† Centers for Disease Control and Prevention. Web. This essay on Obesity: Health or Feminist Issue? was written and submitted by user Leighton H. to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

The Battle of Fallen Timbers essays

The Battle of Fallen Timbers essays The Battle of Fallen Timbers was the key to opening up the Northwest Territory in 1794. There was native unrest in the area and settlers were being killed. Two Generals failed in their attempt to clear the area. The third General, Anthony Wayne, would not fail. This series of events led to the Northwest Territory being more widely settled as well as the eventual statehood of a number of different states. The story of Fallen Timbers begins prior to the actual battle. Colonists had begun to settle the territory before soldiers were able to enter and to move the Native Americans out. The Indians were killing many American citizens. The Indians were not the only group behind the attacks on the American citizens. The British were training, equipping, and giving tactical advice to the Indians (Phelps 4). In the Treaty of Paris of 1783, between America and Britain an agreement was made to allow the British to garrison forts within the Northwest Territory. They were permitted to do so until America settled its differences with the Indians that helped the British in the Revolutionary War. Fort Miami, a British fort, was established in the Northwest Territory. The natives regarded the Ohio River as the boundary between America and their land (Preservation Commission 1). The actual border that was established by the Treaty of Paris was the Great Lakes. The Great Lakes were to be the border between British territory and the American. The British did not want to give up their stake in the Northwest Territory since it was important for the fur trade (Pratt 2). Prior to the Battle of Fallen Timbers, President George Washington ordered soldiers into the Northwest Territory in 1793 to subdue the Indians and push the British out of the Northwest Territory. President Washington first looked to General Josiah Harmar to lead an expedition in pursuit of the goal into the Territory. Harmar was ambushed and his army was quickly des...

Voice of the Customer, and Value Propositions, Southwest Airlines Essay

Voice of the Customer, and Value Propositions, Southwest Airlines - Essay Example Similarly, the airline’s prices are rated ‘good’ compared to those of its competitors whose rating is ‘very good.’ This completely locks out customers who may want to travel on a constrained budget, and creates a field day for Southwest Airline’s competitors. Southwest Airline’s parking is rated at ‘unacceptable’. This is a very sorry state of affairs for the airline, especially if it has any intentions of outdoing other players in the airline industry. By all means, this needs to be fixed urgently to save the airline from further damage. Finally, the airline’s decoration is rated at ‘acceptable’ against its competitor’s rating of ‘very good. This in essence means that customers who value decoration will travel with the competitor airline at the expense of Southwest Airlines. Other areas such as HR and Menu generally enjoy good ratings if compared with Southwest Airline’s competitors. They do not need urgent attention at the moment. In a nutshell, Southwest Airlines must employ more effort to improve the above key areas if it is to remain competitive in the airline industry. This is especially because the airline industry is such that any small thing can adversely affect the performance of an airline. For business class travelers who need to travel frequently between cities, Southwest Airlines will be very convenient. Unlike other airlines, Southwest Airlines has frequent flights between cities and is

Mercks transition to open innovation strategy Essay

Mercks transition to open innovation strategy - Essay Example The paper will focus on the open innovation strategy by Merck pharmaceutical company in form of merging with Schering-Plough. The writer will provide answers to the following questions: 1. Can open innovation help Merck meet the needs of its customers in creative and cost effective ways that also bring value to its shareholders. Why or why not? 2. Assuming open innovative is the path to follow, what implementation issues would you expect? How would Merck overcome its cultural resistance to change? 3. What positive or negative effects will the recent Schering Plough Merger have on Merck’s transition to a more open innovation strategy? Introduction. Merck historically believed in closed innovation strategy. This involves ideas being developed from within the company and the resulting products manufactured and marketed. On the contrary, open innovation involves the search for new ideas from outside and including them in business models. This is through bringing new ideas, personnel and technologies. Open innovation also allows some knowledge to flow outside the companies to other people. Most companies do not use their original technologies because it may be too costly making these ideas unutilized. Open innovations allows some of these good ideas to be shared to companies where they will be put into use. Therefore, open innovations make companies more creative in terms of research and development. ... It has achieved all this success at only one sixth of the cost. Since the approach has worked in other companies, it can also work in Merck. Through open innovation, Merck can develop new cost effective ideas and products. The breakthrough for such products can bring great sales for the company thus benefiting the shareholders. (Rothaemel, 2008) Question 5: Assuming open innovative is the path to follow, what implementation issues would you expect? How would Merck overcome its cultural resistance to change? Merck has been deeply rooted in the culture of closed innovation. This is the culture that they are the best in what they do and need no assistance from outside. Merck assumed that they had the best and brightest personnel. They believe that whatever they invented was the best. Merck believed that all great discoveries were to be unveiled at Merck. This overconfident notion was deeply instilled in the minds of the people at Merck. This makes everyone in the company to be very rigi d to any sought of change. Implementing the new open innovation strategy would therefore, be difficult because of this rigidness. The workers people have strong believe in themselves and would resist any new idea from outside. It would be a problem for the workers at Merck to adapt and accept this change (Rothaemel, 2008). Therefore, for successful development of open innovation at Merck, change has to start with each person. Change from the use of closed innovation to open innovation would mean that people have to change their attitudes and minds. This would erase the earlier culture of closed innovation and replaced it with open innovation. The resistance to change can be dealt with by sending top

Graphene Oxide (GO) as Antimicrobial Property

Graphene Oxide (GO) as Antimicrobial Property Over the past several years scientists have studied graphene materials (graphene, graphene oxide and reduced graphene oxide) for its antimicrobial properties and its future application in the biomedical field. To date, the exact mechanism for why graphene and its derivatives have antibacterial properties has not been fully understood due to experimental design variables. Scientists have agreed that oxidative stress, phospholipid extraction, and nanoknives all play an important role in the antibacterial properties of graphene materials. There are several techniques such as scanning electron microscopy, transmission electron spectroscopy, and mass spectroscopy that have been used to monitor change in morphology and cell death after exposure to graphene and its derivatives. Through these techniques scientist have been able to confirm that graphene materials are able to promote cellular death in both gram-positive and gram-negative bacteria, leading to its promising future also in pharma ceuticals. Graphene is a two-dimensional hexagonal structure, consisting of a basal plane (along the surface) and lateral edges, that are made up of sp2 hybridized carbons which form a conjugated à Ã¢â€š ¬ system. This à Ã¢â€š ¬-conjugated system makes graphene very hydrophobic and able to interact with the hydrophobic cell membranes of bacteria. Graphene oxide (GO) is most commonly prepared using the Hummers method, which consists of a multi-step synthesis. First the graphite material is oxidized to form graphite oxide and then this is exfoliated via sonication to form a single layer of material called GO. Through the oxidation process oxygenated functional groups are introduced into the basal surfaces and lateral edges of GO. On the basal surface of GO, the functional groups of epoxides and hydroxyl groups are present, whereas, the larger groups such as carboxyl and carbonyl groups form along the lateral edges. It is important to note that with the introduction of the oxygenat ed functional groups, the basal plane and lateral edges will need to adopt sp3 hybridized carbons, which results in the formation of defect regions where the à Ã¢â€š ¬-conjugated system is broken. The presence of these defects will be explored in more detail below as these areas are critical in the antibacterial properties of GO. In the literature, GO and other graphene materials have demonstrated through both physical and chemical mechanisms they have the ability to reduce bacterial cell count of both gram-negative and gram-positive bacteria1. Several pivotal studies have been conducted in order to determine the key mechanism behind the antibacterial properties of GO. Nada et.al studied the antibacterial mechanisms using Raman spectroscopy2, Zhang et.al studied the antibacterial activity using mass spectroscopy3, and Yusong et.al examined the effects of extraction of phospholipids from E-coli by graphene nanosheets4.These studies have led to the development of several mechanisms including the cutting of the membrane wall by the sharp edges of the defect sites (nanoknives), phospholipid extraction and oxidative stress. The various experiments to date regardless of experimental design demonstrated that it is not a single mechanism that is responsible for the antibacterial properties of GO but rather a combinat ion of several mechanisms that can contribute to the overall antibacterial properties. Ultimately, it is the breakdown in the cell membrane that causes intracellular leakage of vital proteins, nucleic acids, and cytoplasmic material that results in the loss of reproduction and cell death. The cutting mechanism also referred to in the literature as nanoknives is one of the most important mechanisms that lead to the antibacterial properties of GO. The sharp lateral edges of GO are able to penetrate into the cell membranes inner and outer layer. This leads to the loss of cell membrane integrity and leakage of intracellular materials such as the cytoplasm, nucleic acids, proteins and amino acids. Nada et al used a variety of techniques, such as Raman spectroscopy and scanning electron microscopy (SEM) to observe the cellular changes (deformation or loss of cell membrane integrity) of bacteria, such as E Coli when exposed to varying concentrations of GO material. Raman spectroscopy was used to determine how E.coli reacts to an increasing concentration of GO. From the research done by Nada and team the bands with the greatest change were those of adenine (a nucleic acid) (729cm-1), the S-S stretching vibrations (490cm-1) of the disulphide bonds (found on the surface of the cell) and the amide group (found in proteins) bending vibration at 610cm-1.2 The intensity of each of these bands increased with the increase in GO concentration. This positively confirms that GO had penetrated into the cell membrane, causing the loss integrity and allowing the intracellular material such as adenine and other proteins to leak from the cell. Once this material was leaked from the cell, its vib rational absorption increase the signal in the Raman spectrum intensified. The examined the effects of GO on E. coli using SEM was used to observe the morphological changes in cells after exposure to GO. Figure 1 below, shows the morphological effects on E. coli with increasing GO concentration2. Image A represents the control of E. coli cells. In image B, E. coli was treated with low concentration of GO causing morphological changes seen by the distortion (flattening or squishing) of the rod shape. As the concentration of the GO treatment increases the sharp edges of the GO material are able to penetrate into the cell membrane (as seen in the red arrow in image c) and lead to a loss of cell membrane integrity resulting in the leakage of the intracellular material. 2 This effect was not isolated to only gram-negative bacteria but also gram-positive bacteria as well, in which the thickness of the cell membrane is different however similar results were observed. Therefore, the thickne ss of the cell membrane does not play a critical role in the nano-knife cutting mechanism as GO was able to penetrate both the inner and outer cell membrane walls. The size of the GO also plays a key role in the cutting ability of GO due to the changes in the basal plane and lateral edges. A study lead by Perreault examined how altering the size of GO changed the cell viability of E. coli. GO sheets were altered by varying the sonication time and power in order to obtain GO sizes ranging from 0.65  µm2 down to 0.01  µm2.5 Using live/dead fluorescence staining it was determined that there was no change in cell viability (%living) when the bacteria was not in contact with GO as shown in the control of figure 2.5 The green dots represents the number of colony forming units (CFU) alive and the red dots are dead CFUs. The smaller sheet size of 0.01  µm2 has significantly lower cell viability (30%) when compared to the 0.65  µm2 sheet (73%).5 This phenomenon is explained by the fact that as the size of the GO material is decreased the amount of defects in the sp2 hybridized carbons of the basal plane and edges increases. T he defects are caused by either the addition of oxygen groups or shrinkage in size that destroys a portion of the basal plane. This effect creates additional sharp edges in both the lateral edges and basal plane leading to more nanoknives that are capable of cutting through the cell membrane. This allows for increase areas of interaction with the bacterial. This was also confirmed using SEM where larger sheet sizes (0.65 µm2) showed very little deformation and almost normal cell structure whereas smaller sheets (0.01  µm2) appeared to be flattened and deformed leading to a compromised cell structure5. It is interesting to note that the amount of surface defects also plays a critical role in the formation of reactive oxygen species (ROS) that will create oxidative stress to the cell membrane and additional loss of membrane integrity. Therefore, it is impossible to determine if only the physiochemical mechanism of cutting is the single mechanism that impacts cell viabili ty or multiple mechanisms do. In reality, with smaller GO size the loss of cell membrane integrity and intracellular leakage can be attributed to both the nano-knife effect and oxidative stress due to the increase in defects. This mechanism also has been shown to work in combination with other mechanisms such phospholipid extraction in which after cutting into the cell membrane the phospholipids are better able to be extracted by GO. This effect is due to hydrophobic attraction between the phospholipid tails and the à Ã¢â€š ¬-conjugated sp2 carbons of the basal plane. This will be discussed in further details in the later sections. GO is highly hydrophobic due to the à Ã¢â€š ¬-conjugation of the basal surface which allows it to interact with the phospholipid layer of the bacterial cell membrane. The oxygenated groups on GO provides a hydrophilic portion of the compound that is able to interact with the polar heads of the phospholipids. Yusong et al performed a detailed experiment on this and showed that extraction of the phospholipid molecules via hydrophobic interactions causes cell membrane deformation and collapse.5 There are two main mechanisms for the extraction of the phospholipids depending on the size of the GO material. With larger GO materials, the nanosheet will lie along the cell membrane causing a disruption of the phospholipid membrane; allow the GO material to embed itself into the lipophilic portions of the membrane1. For smaller GO materials, the sheet will lie perpendicular to the membrane and penetrate through the cell membrane (either partially or completely) via the nano-knife mechanism. This further supports the theory that it is not a single mechanism that allows for the antibacterial properties but a combination of several. The extraction of phospholipids occurs in several steps (see Figure 3). The first step involves a slight shifting of phospholipids due to the docking of the GO nanosheet as described by Yuesong (Image a).4 Next the phospholipid head will begin to break through the cell membrane and climb up the GO sheet (image b). This climbing effect is observed as result of the strong attractive forces between the hydrophobic regions of the basal plane and the hydrophobic tails of the phospholipids. This extraction process will continue until the GO material is covered completely with phospholipids with several layers of phospholipids climbing at the same time (image d). The phospholipids will evenly spread over the surface in such a way that the hydrophobic tails will align with the hydrophobic regions of the basal surface and the polar heads will align with the oxygenated functional groups of GO (images e and f).4 The loss of the phospholipids from the cell membrane causes a loss in membrane dens ity which weakens the cell membrane. Due to the loss of density and the penetration of the GO into the cell, cell membrane integrity is lost resulting in the leakage intracellular fluids. This effect can be seen with the aid of TEM as morphological changes are easily identified using this method of analysis (see figure 4)4. Image A represents the initial state in which no morphological changes have occurred when E-coli was treated with GO.4 Over time as the phospholipid extraction occurs, the cell membrane density will decrease as shown in images b and c seen by the Type B arrows. The last step in the process is when cell integrity is lost and the intracellular material begins to leak. This effect is also observed in the images d-f where the cells are transparent due to loss of the cytoplasm4. This confirms that the phospholipid extraction occurs with the aid of the nanoknives leading to loss in cell viability. Another group of scientist lead by Zhangs used mass spectroscopy to map the metabolites of E-coli before and after exposure to GO.3 A typical mass spectrum of E-coli without GO treatment is shown Figure 5a. The most important peaks are at m/z 306 which corresponds to glutathione (GHS), which is an antioxidant commonly found in E. coli, and the membrane phospholipids phosphatidylethanolamine (PE) and phosphatidylglycerol (PG), at approximately m/z 600-8003. As the concentration of GO increased the overall intensities of the GSH, PE and PG all decreased (see fig 5b). This aligns with the previous studies of Yusong in which the extraction of the phospholipids leads to a decrease in cell membrane density. This was clearly observed by the decrease in signal intensities of both PE and PG. In the mass spec results obtain by Zhangs team there was also a decrease in GSH intensity. GSH is a critical antioxidant found in E. coli and will act as a scavenger for any free oxygen radicals that may be present in the bacterias environment. GSH prevents the oxidative breakdown of the phospholipid membrane that can also lead to a loss of cell membrane integrity and intracellular leakage. This finding confirms the previous hypothesis that there are many mechanisms running in parallel that ultimately attribute to the overall antibacterial properties of GO. In this very example, the nano-knives are able to cut into the phospholipid membrane and start the chain reaction of phospholipid extraction. This extraction causes a decrease in phospholipid density which in parallel with the cutting of the membrane by the nanoknives and oxidative stress leads to a loss in cell membrane integrity. This loss in cell membrane integrity leads to a loss of intracellular material such cytoplasmic mate rial, nucleic acids and proteins.. As demonstrated by the mass spectrum results obtained by Zhang et al, oxidative stress occurs when there is a decrease in antioxidant concentration (such as GSH)3. The consumption of GSH occurs in the presence of reactive oxygen species (ROS) which are typically composed of hydrogen peroxide (H2O2), superoxide anions (O2*), hydroxyl radical (OH*) or singlet molecular oxygen species(1O2)1. When the antioxidants (such as GSH) are depleted the ROS compounds will then cause oxidation of key lipids in the cell membrane, proteins or even nucleic acids. The formation of the ROS compounds occurs due to the very nature of GO. When graphite is oxidized to form graphite oxide, the basal plane obtains additional defects as the result of the loss of à Ã¢â€š ¬-conjugation. This loss of à Ã¢â€š ¬-conjugation occurs due to the introduction of the oxygenated functional groups such as epoxides and hydroxyl groups which creates sp3 hybridized carbons. The introduction of the sp3 carbons alters the planer geometry of the basal plane by introducing tetrahedral carbons, creating defects in the lateral edges and basal plane. Additional defects can also be introduced as mentioned in the previous section when the size of the GO material is decreased. As the size of the sheets decreases the ability of the GO to stay as a perfect hexagonal structure also diminishes as the structure gets distorted to accommodate the smaller size. The process of oxidative stress begins with the formation of ROS compounds. Oxygen is absorbed to the surface of the basal plane or lateral edges at the defects sites to form surface oxides. These surface oxides release ROS species in the presence of antioxidants as a result of a redox reaction. In the presence of GSH (an antioxidant found in E. coli), the surface oxides found on GO are reduced by an electron transfer from GSH. Another GSH molecule will then donate a proton to the ROS species, causing its reduction and subsequent release of a water molecule.5 The deprotonated GSH molecule will then react with another GSH molecule to form glutathione disulphide. If GSH is not available, the ROS species will then oxidize the lipids in the cell membrane to form as a lipid peroxide radical causing oxidative stress to the cell membrane. This oxidative stress will continue down the cell membrane until the lipid peroxide radical encounters an antioxidant bound to the cell membrane such as V itamin E. It is important to keep in mind that with an increased amount of free oxygen radicals the extent of oxidative stress increases and the overall cell integrity decreases. As mentioned earlier, the size and shape of the GO plays a key role in determine the extent of the oxidative stress. As the size of the GO material decreases from 0.065 to 0.01 µm2 the amount of surface defects increases. Again this is due to the loss of the conjugation and destruction of the basal plane. With the smaller GO material the presence of additional defects allows for the formation of many more surface oxides that can later be reduced to form ROS compounds. These ROS compounds then will continue to deplete the antioxidants and lead to further lipid peroxidation. This effect will continue until enough oxidative stress exists to cause the membrane to collapse and bacterial death to occur. Perreault and team demonstrated this effect when they examined through Raman spectroscopy and cell viability testing that the size of the GO material plays a critical role in the ability of the material to induce oxidative stress. Figure 6 shows that as the size of the sheet decreases, the amount of disorder due to the defects (D band) increases. Therefore there is a direct correlation to number of defects and the ability of GO to form ROS species that interact with GSH. This is further confirmed with the graph in figure 6a which shows the %loss of GSH decreases with the increase in GO size. Therefore it not only the nanoknives that that are influenced by the size of GO but also oxidative stress due to the adsorbed oxygen and ROS formation. As demonstrated through the various studies conducted by Nada et al, Zhang et.al, and Yusong et al the key antibacterial mechanisms of GO are cutting via nanoknives, phospholipid extraction and oxidative stress that contribute to the overall antibacterial properties of GO. The research to date indicates it is not a single mechanism that creates the antibacterial properties of GO but a combination of all factors. How much antibacterial is dependent on the physical size of GO plays and the number of defects in the basal surface and lateral edges. As the size of GO decreases a larger degree of surface defects forms. These defects play two important roles in the antimicrobial properties of GO. First, an increase in surface defects creates an increase in the number of sharp edges that causes a loss of cellular membrane integrity. Directly, the cell membrane is compromised by the penetration of the nano-knives resulting in intracellular leakage of the cytoplasm, amino acids, proteins and n ucleic acids, Indirectly, once the nano-knives cut into the cell membrane it becomes embedded through attractive force between the hydrophobic tails of the cell membranes phospholipids and basal plane promotes phospholipid extraction. This extraction causes a decrease in cell membrane density which further breaks down the membrane causing additional intracellular leakage of key nucleic acids, cytoplasm and proteins. Lastly, the increase in surface defects of the basal plane increases the presence of reactive oxygen species. These species will react with any antioxidant present in the bacterial cell depleting their levels. Once depleted or reduced, the ROS will cause oxidation of the cell membrane lipids leading to a chain reaction of oxidative stress through the cell membrane. This also will lead to a loss of cell membrane integrity and intracellular leakage of key proteins and nucleic acids responsible for cell growth and replication. Without this material the bacteria cell will di e leading to the antibacterial properties observed in GO. With the development of drug resistant bacteria, new and inventive ways to treat bacterial infections need to be explored. GO with its unique chemical and physical properties show much promise as the next antibacterial treatment. Additional studies need to be conducted to determine the cytotoxicity of GO in animals and humans in order to development new treatment therapies. Zou,X.; Zhang, L.; Wang, Z., Luo, Y. Mechanisms of the Antimicrobial Activities of Graphene Materials. J. Am. Chem. Soc. 2016, 138, 2064-2077 Nada, S.S; Yi, D.K; Kim, K. Study of antibacterial mechanisms of graphene oxide using Raman spectroscopy. Sci. Rep. 2016, 6, 28443; doi: 10.103,srep28443 Zhang, N.; Hou, j.; Chen, S.; Xiong, C.; Liu, H.; Jin, Y.; Wang, J.; He, Q.; Zhao, R.; Nie, Z.. Rapidly probing antibacterial activity of Graphene oxide by Mass Spectrometry-based metabolite fingerprinting Sci. Rep. 2016, 6, 28045; doi: 10.1038,srep28085 Yusong, T.; Lv, M.; Xiu; Huynh, T.; Zhang, M.; Castelli, M.; Liu, Z.; Huang, Q.; Fan, C.; Fang, H.; Zhou, R. Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets. Nat. Nanotechnol. 2013, 8, 594-601, doi:10.1038/nnano.2013.125 Perreault, F.; Fonseca de Faria, A.; Nejati, S.; Elimelech, M. Antimicrobial Properties of Graphene Oxide Nanosheets: Why Size Matters. ACS Nano. 2015, 7, 7226-7236

Cognitive Interventions Essay

The only thing that tells everyone apart from everyone else is each person’s genetic make-up. And there is only one exception and that would identical twins, because no two people are the same. This can be said true about the way we all think. There is no one person that thinks the same as the next person. People believe that we are all born innocent and that we are pure in thoughts and in behavior. There are many different factors that can and sometimes do influence how a person is controlled by his/her cognitive ability to think before acting. There are people who do a better than others can. There are people who have certain psychological problems that seek out help from a therapist to get a handle on their problems. One of most popular therapy would be cognitive behavior therapy (CBT). The base of this theory is that some of the behaviors are caused by a person’s inner thoughts or by mental inability to deal with problems or events in our lives. In this paper, I will summarize the article â€Å"Abuse-Focused Cognitive Behavioral Therapy for Child Physical Abuse,† that describe Abuse-Focused Cognitive Behavioral Therapy (AF-CBT) and the use of AF-CBT in adolescent anger management. Article Summary Childhood anger can be tiger by many different factors, thoughts or even events during a child early life. A young child is not able to express their feels in a correct way, so they have problems in dealing with their anger. This could also be that they were never taught by his/her parents how to handle their emotions. A good example would be a friend of mine that has a child with some deep rooted problems, When Sam get angry he will not able to express how he feels so he acts out towards anyone that is near him. At Christmas time I brought him a soccer ball that he wanted and when he opened it he just threw it to one side, so he was punishment, sent to his room, when he came out the looks in his eyes just plain scared me. I have seen that look in a person who just committed a murder. Cold and dark look is what this child has. Most children with this type of problems, it could be a result of abuse in the home by one or both parents, and the type of abuse could be physical or sexual. At the time of the abuse the child may feel that they could not fight off the person who is abusing him or they are so scared to tell anyone. When this time of situation has occurred the child is not able to handle so they will out and get into trouble. They may start getting into trouble at school, start handling out with the wrong crowds and getting into serious trouble with the law. The child may become involved with sex, alcohol and drugs, sometimes the child could turn out to be an abuser also. Children will do this to get away from their home life and the pain. If the abuse was discover at an early age, and then the child can be remove from the home and has a better chance to get therapy and could turn out to normal. This way the hate and anger can be redirected to a more positive avenue. It difficult for a child to understand why things happened to them and but to be able to speak to someone that can be able to help them understand that it was no their fault and help them heal their emotional wounds. Unfortunately, the affective of the abuse may follow the person throughout their life in many different forms. It can affect their children and even their partners. They may became have problems like becoming overweight so they will not be attractive to men. They also can be very sexually active. Being in therapy as a child they can be with other children that have been threw the same as the child and could help to release their anger, it could also help them from staying away from trouble and from hanging out with the wrong people. This would help the child to focus more on school and what is important to the child. The cognitive behavior theory is known to help child that are victims of abuse cases whether it is physical or sexual and the parents that are the abusers, that may help them to reestablish a relationship between parents and children. Abuse-Focused Cognitive Behavioral Therapy  The main usage of the Abuse-Focused Cognitive Behavioral Therapy (AF-CBT) is working with children and their families that have suffered sexual or physical abuse; the environment is very hostile, the child may be subject coercion and are aggression when the family is present. AF-CBT is also used for children with behavioral problems such as Conduct Disorder and Oppositional Defiant Disorder. AF-CBT is right for children who are the ages of 5-15, who exhibit some level of behavioral or emotional dysfunction and for parents or caregivers who may resort to uncomfortable or unsafe levels of physical punishment. The goal of this therapy is to reduce the level of physical abuse risk factors of the caregiver or family and to reduce the consequences of these experiences for the children. The primary focus is behavior management, social skills, training, cognitive restructuring, problem-solving skills, and communications skills for the caregiver’s level of anger and promote nonaggressive discipline strategies, to enhance a child’s coping skills, and encourage problem-solving and communication. There are three stages of AF-CBT process, each of the steps consisting in multiple steps that involve the child and the parent(s) separately and jointly. This type of treatment would be taken place as outpatient or in a setting that ongoing contact with the caregiver and the child. The treatment should take place twice a week for approximately three to six months. Abuse-Focus Cognitive Behavioral Therapy in an Adolescent Anger-Management, the important part is to be able know how to control anger. Everyone can control their anger and being angry is a normal part of life. Just like everyone else, adolescent are no exception. The only exception is that adolescent can take their anger to the extreme and their action may not be called normal when angered. There is one way to help the adolescent to control their anger is by cognitive therapy. Cognitive behavioral therapy can occur in many different ways, the most common is the one-to-one talk with the adolescents. Once the problem is out in the open, the therapist may give the adolescent advice and to show how to control or redirected their anger. It is a success when one discovers the problem using the cognitive behavioral therapy. Now that the adolescent is able to control their anger it more benefit for those who are around the adolescent, it does benefit both parties. With aggressive or violent behavior the AF-CBT will target in three ways in which people can deal with the situations: 1) Cognition (thinking), 2) Affect (feeling), and 3) Behavior (doing). AF-CBT use many different techniques that are used by practitioners, such as behavior and anger management, problem solving, social skills training, and cognitive restructuring. All programs require proper training in different areas, especially with psychological skills so that enhancing interpersonal effectiveness and self-control is maintained. Conclusion The article explains to us how to deal with child and adolescent in dealing with their anger due to physical or sexual abuse to them and to be able overcome their anger and to deal with feelings as well as their families. The primary goal of AF-CBT is to reduce other behavioral problems in children and adolescent when they grow-up.

The Gifted

Not all of us can do great things. But we can do small things with great love. † Mother Teresa A day of extending the service of love was once again showed by the grantees to the children of orgy. Barras, Stop. NIH. It was a day full of happiness that the grantees, though they didn't have expensive things to share, and fancy gifts to give, didn't fail the children experience the feeling of being loved through sharing with them the Joy and laughter that no amount of money could ever buy.It was a day of fun when the renters conducted several activities in cooperation with the Christ the King College- College of Teacher Education Graduating Class of 2013. The KC-CITE together with the grantees of Cassis Development Foundation had an outreach program exclusively for the students of Barras Elementary and Secondary Schools. The grantees were able to show their spirit of generosity not Just by sharing largesse to the learners of Bray. Barras but also by giving them knowledge and under standing of things that are still alien to them, giving them awareness of the scholarships offered at Christ the KingCollege, most specifically the Cassis Development Foundation, and of course sharing with them a barrel of laughs. Just looking into the eyes of those children, their eagerness and enthusiasm of pursuing their studies and the realization by themselves that cried how unfortunate they were not to do so because of financial instability made the hearts of the grantees moved†¦ And this was the highlight of their visit on that place. Subsequently, the only thing that emanated to the grantees was to open the gates for them by sharing with the learners the idea that both sides share the same sentiments specially before.The grantees disclosed with them their past stories before they became grantees, the grantees wanted the learners to understand that in every problem there will always be a solution, that there is always a chance for the unfortunate, and a hope to those who believe. The UDF grantees gave inspiration to the learners to not lose hope but fight instead to whatever circumstances they may be facing for life is sometimes cruel but it can yield the sweetest thing if one learns how to look into its positive side. The outreach program did not Just wake up the hearts and minds of the people in orgy.Barras but it also rough them enlightenment unto which path to go through and it was really an honor that the Cassis grantees were also a part of that realization in their lives. Through the grantees' initiative of uncovering their life stories for the sake of giving the students the encouragement and motivation to continue to the course of their lives through educating themselves, truly they presented their being of a teacher with Franciscan values with them. The grantees believe that they can make a difference through commencing with simple things, thus, according to Napoleon Hill, whatever the mind can conceive and believe, it can achieve.